Minor (one)pentobarbital will decrease the extent or influence of paclitaxel protein bound by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar. pentobarbital will decrease the level or impact of clozapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. pentobarbital will decrease the extent or effect of elagolix by impa... https://grahamh655dtj4.wikiconversation.com/user