Opioid action is due to equally very low affinity binding of the mum or dad compound and higher affinity binding of your O-demethylated metabolite M1 to µ-opioid receptors. In animal styles, M1 is up to 6 moments far more potent than tramadol in making analgesia and 200 periods a lot https://anthonyd701ztl4.shoutmyblog.com/profile